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L., et al., “Nigrostriatal Dopamine System Dysfunction and Subtle Motor Deficits in Manganese‐Exposed Non‐Human Primates,” Experimental Neurology 202 (2006): 381–390, 10.1016/j.expneurol.2006.06.015

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If the liver is overwhelmed by toxins or oxidative stress, it cannot perform these metabolic tasks efficiently