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For tissue and joint regeneration, PRF has the advantage of causing platelets to bind to fibrin, which initiates biochemical activation of certain cells, platelets, and growth factors and also provides an organized scaffolding matrix and natural fibrin glue to help heal structural tissue damage

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Dendritic cells may also indirectly contribute to fibrogenesis by regulating profibrotic immune cell populations, such as CD8 + T cells (80)