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Empty pACAd5-IRES-GFP vector was utilized as the control

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Mice lacking one of the alleles of the COQ7 gene ( mCOQ7/mCLK1 gene ) show extended longevity even though their CoQ levels are the same as wild-type mice, suggesting that a factor other than CoQ per se may be responsible for lifespan extension in these animals (Lapointe and Hekimi, in vivo studies have reported a direct association between longevity and mitochondrial levels of CoQ in the Samp1 model of senescence-accelerated mice (Tian et al., 2014)