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551 In summary, CD8+ TRM cells (which produce IL17) together with CD4 + TRM cells (which secrete IL-22 after the stimulation of IL-23 produced by epidermal Langerhans cells) induce keratinocyte hyperproliferation and subsequent disease relapse in resolved lesions

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6.1 Diabetes Type I diabetes, Type II DM, and gestational diabetes are characterized by hyperglycemia, dyslipidemia, and insulin resistance, which increase oxidative stress and activate the protein kinase C (PKC) as well as the receptor for advanced product glycation (AGE) and low levels of antioxidants and GPx in diabetic patients