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Identification of novel lncRNAs differentially expressed in placentas of Chinese Ningqiang Pony and Yili horse breeds

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Cancer-linked CGI hypermethylation in already repressed promoters Introduction of high levels of DNA methylation throughout an active CpG-rich promoter region of protein-coding or non-coding genes (ncRNA genes) is almost always associated with repression of that gene’s transcription unless the gene contains an alternative unmethylated promoter (Figure 1a, f) [19,33,58,59]