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Unlike caffeine-based thermogenics or GLP-1 agonists, Tesofensine works through a completely different mechanism

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Damage to the BBB typically occurs within minutes to hours following the injury and involves generation of reactive oxygen species and the activation of matrix metalloproteases (MMPs), such as MMP-2, MMP-3 and MMP-9 and MMP-12 that degrade the basement membrane, tight junction proteins and damage cellular components of the neurovascular unit, such as pericytes