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Supplementary material The Supplementary Material for this article can be found online at: Glossary IR Ionizing Radiation TfRs Transferrin Receptors ROS Reactive oxygen species GSH Synthesis of glutathione GPX4 Glutathione peroxidase 4 MDA Malondialdehyde PUFAs Polyunsaturated fatty acids ALOXs Lipoxygenases SLC3A2 Solute carrier family 3 member 2 SLC7A11 Solute carrier family 7 member 11 AIFM2 Apoptosis-inducing factor mitochondria-associated 2 FSP1 Ferroptosis suppressor protein 1 CoQ Ubiquinone/Coenzyme Q CoQH₂ Ubiquinol RTA Radical-trapping antioxidant DHODH Dihydroorotate dehydrogenase GCH1 GTP Cyclohydrolase 1 BH4 Tetrahydrobiopterin ACSL4 Acyl-CoA synthetase long-chain family member 4 BMP4 Bone morphogenetic protein 4 SAT1 Spermidine/spermine N1-acetyltransferase 1 DPP4 Dipeptidyl-peptidase-4 AGPS Alkylglycerone phosphate synthase ELOVL5 Eongation of very long-chain fatty acid protein 5 FADS1 Fatty acid desaturase 1 EMT Epithelial-mesenchymal transition ZEB1 Zinc finger E-box binding homeobox 1 CDH1 Epithelial anchoring protein E-cadherin HIF-1α Hypoxia inducible factor 1α HILPDA Hypoxia-inducible lipid droplet-associated protein EGFR Epidermal growth factor receptor VHL Von Hippel–Lindau IDH1 Isocitrate dehydrogenase 1 2-HG 2-Hydroxyglutarate NF2 Cadherin-neurofibromin 2 YAP Yes-associated protein TAZ Transcriptional coactivator with a PDZ-binding motif NOX4 NADPH oxidase 4 CTAB Hexadecyltrimethylammonium bromide HILPDA Hypoxia-inducible lipid droplet-associated protein PLIN2 Perilipin 2’OA, Oleic acid POA Palmitoleic acid ATM Ataxia telangiectasia mutated PARP1 Poly(ADP-ribose) polymerase 1 DNA-PK DNA-dependent protein kinase MPF Mitosis-promoting factor 2-DG 2-Deoxy-D-glucose HNSCC Head and neck squamous cell carcinoma SOD Superoxide dismutase O2- Superoxide anions UVB Ultraviolet B SIRT6 Sirtuin 6 MSCs Mesenchymal stem cells VEGF Vascular endothelial growth factor CDKs Cyclin-dependent kinases ER Endoplasmic reticulum NF-κB Nuclear factor κ-B AP-1 Activator protein 1 Na2S Sodium sulfide -SH Sulfhydryl Ara-C Cytosine Arabinoside METTL14 Methyltransferase 14 References 1 JaffrayDA

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Serum was obtained by centrifuging blood samples at 10,000 g for 5 min and stored at –80 °C