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The amount of a biomarker in a subject is "significantly" higher or lower than a normal amount of the biomarker if the amount of the biomarker is greater than or less than, respectively, an amount greater than or equal to the standard error for the determination of the assessed amount and preferably greater than or less than at least 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 300%, 350%, 400%, 500%, 600%, 700%, 800%, 900%, 1000% of the amount compared to the normal level
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