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This quick clearance limits the delivery of therapeutic payload over the long period of time for which the mucoadhesion is designed, reducing the bioavailability of inhaled therapeutics 145

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Thioredoxin reductase 1 TXNRD1 gene encodes a pyridine nucleotide oxidoreductase that functions in selenium metabolism and oxidative stress protection by reducing thioredoxins and other substrates (74)