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Acute injuries may respond adequately with shorter protocols (6-8 weeks), while chronic degenerative conditions like osteoarthritis may benefit from extended maintenance periods of 12 weeks or longer

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At the heart of these processes are the NF-κB and MAPK signaling pathways, which control the transcription of pro-inflammatory mediators including COX-2, CRP, LOX-2 and cytokines IL-1, IL-6, IL-8 and TNF-α (97–99)