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Notably, both cancer cells and immune cells in the TME often co-express βARs, laying a molecular foundation for their regulatory role in tumor biology ( CIH, a core pathophysiological feature of OSA, can continuously activate the sympathetic nervous system to release catecholamines, thereby triggering the βARs signaling pathway and promoting lung cancer progression (Powell et al., 2013

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Various topical, oral, and injection-based cosmetic skin-lightening agents with different mechanisms of action are used widely across Asia, including hydroquinone, azelaic acid, kojic acid, mulberry, alpha-arbutin, beta-arbutin, glutathione, licorice root, papaya, vitamin A (e.g., retinol), vitamin B (i.e., niacinamide), and vitamin C