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Interestingly, this is in sharp contrast to and potentially complementary to UPS regulators, suggesting that future treatment strategies can evolve from “single target” to “multi-target synergy.” For example, the combination of compounds that can activate proteasome or E3 ligase and anti-Aβ antibody can theoretically form the effect of “internal and external treatment”: the antibody is used to remove the plaque formed outside the cell, while UPS regulator is responsible for removing the Aβ oligomer and phosphorylated tau in the cell, so as to produce a synergistic effect, improve the efficacy and safety, and reduce the risk of possible side effects

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2014 doi: 10.1002/14651858.CD010405