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FB9s-b selectively inhibits GluK1, GluK2 and its heterodimer with GluK5, and FB9s-r inhibits AMPAR, and the stability of both of them was significantly improved by the 2′-fluorine modification, and they retained the selectivity for their respective receptors and similar inhibition potency as before, and maintained the selectivity for the respective receptors and the inhibitory potency similar to that before the modification [181]