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TIER 1 (10mg total) $219 total for 10 week supply Monthly cost breakdown: $88 Recommended if new to treatment or for those on 0.2-1mg/week TIER 2 (15mg total) $229 total for 10 week supply Monthly cost breakdown: $92 Recommended for those on 1.1-1.5mg/week TIER 3 (20mg total) $249 total for 9-10 week supply Monthly cost breakdown: $90-$100 based on weekly dose Recommended for those on 1.6mg/week and up TIER 4* (30mg total) $365 total for 8-10 week supply For patients approved to be on high dose therapy of 3-4mg per week Monthly cost breakdown: $146-$182 based on weekly dose TIER 5* (45mg total) $465 total for 8-10 week supply For patients approved to be on high dose therapy of 4-5mg per week Monthly cost breakdown: $186-$232 based on weekly dose Vios Pharmacy - Semaglutide/Levocarnitine Injection (NEW) Up to 90 days BUD

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Treatment with DNA methyltransferases (DNMTs) inhibitor 5-aza-2′-deoxycytidine (5-Aza) and histone deacetylase (HDAC) inhibitor trichostatin A (TSA) has shown to restore the epigenetically silenced Nrf2 gene and increase NQO1 expression, which helps to prevent prostate cancer progression in TRAMP mice and protects against Alzheimer’s development in a mouse neuroblastoma N2a cellular model (Yu et al., 2010